Antidiabetic activity of methanol extract and fractions of Costus speciosus leaves in normal and alloxan induced diabetic rats

Introduction: Costus speciosus is a common plant used for the treatment of diabetes mellitus and various other ailments in traditional medicine Sri Lanka. The present study was conducted to investigate hypoglycemic effect leaves C. both normal alloxan induced male Wistar diabetic rat models. Methods: A methanolic extract produced preliminary phytochemicals screening. Methanol further partitioned with different solvents (n-hexane, chloroform, ethyl acetate n-butanol) according their polarity. Male rats weighing 150-220 g were randomly divided during test. In vivo antidiabetic activity fractions performed NIDDM rats. Standard t-test determine statistical significance. Results: glucose tolerance test indicated that peak levels blood reached 90 minutes after load. It noteworthy group recorded significantly (p < 0.05) lower level at minutes, indicating 80 % methanol exerted an overall despite being challenged same dose showed improvement alloxan-induced rats, reducing by 60 compared control. These effects found be comparable synthetic drug glipizide 20 mg/kg. long term administration 80% daily 6 weeks resulted significant lowering fasting postprandial serum when control Conclusion: Diabetic treated displayed (p<0.05) decreased group.
 Keywords: Alloxan, speciosus, mellitus, hypoglycemia, anti-hyperglycemia